Publications

Bessueille L, Kawtharany L, Quillard T, Goettsch C, Briolay A, Taraconat N, Balayssac S, Gilard V, Mebarek S, Peyruchaud O, Duboeuf F, Bouillot C, Pinkerton A, Mechtouff L, Buchet R, Hamade E, Zibara K, Fonta C, Canet-Soulas E, Millan JL, Magne D. Inhibition of alkaline phosphatase impairs dyslipidemia and protects mice from atherosclerosis. Transl Res. 2023 Jan;251:2-13. doi: 10.1016/j.trsl.2022.06.010. Partners 1 and 3

Heuschkel MA, Babler A, Heyn J, van der Vorst EPC, Steenman M, Gesper M, Kappel BA, Magne D, Gouëffic Y, Kramann R, Jahnen-Dechent W, Marx N, Quillard T, Goettsch C. Distinct role of mitochondrial function and protein kinase C in intimal and medial calcification in vitro. Front Cardiovasc Med 2022 Sep 20;9:959457. doi: 10.3389/fcvm.2022.959457. Partners 1 and 3

Kawtharany L, Bessueille L, Issa H, Hamade E, Zibara K, Magne D. Inflammation and Microcalcification: A Never-Ending Vicious Cycle in Atherosclerosis? J Vasc Res. 2022 Jan 17:1-14. Partner 1

Briolay A, Bessueille L, Magne D. TNAP: A New Multitask Enzyme in Energy Metabolism. Int J Mol Sci. 2021 Sep 28;22(19):10470. Partner 1

Canet-Soulas E, Bessueille L, Mechtouff L, Magne D. The Elusive Origin of Atherosclerotic Plaque Calcification. Front Cell Dev Biol. 2021;9:622736. Partner 1

Kawtharany L, Bessueille L, Issa H, Hamade E, Zibara K, Magne D. Inflammation and Microcalcification: A Never-Ending Vicious Cycle in Atherosclerosis? J Vasc Res. 2022 Jan 17:1-14. Partner 1

Briolay A, Bessueille L, Magne D. TNAP: A New Multitask Enzyme in Energy Metabolism. Int J Mol Sci. 2021 Sep 28;22(19):10470. Partner 1

Canet-Soulas E, Bessueille L, Mechtouff L, Magne D. The Elusive Origin of Atherosclerotic Plaque Calcification. Front Cell Dev Biol. 2021;9:622736. Partner 1

Goettsch C, Strzelecka-Kiliszek A, Bessueille L, Quillard T, Mechtouff L, Pikula S, Canet-Soulas E, Millan JL, Fonta C, Magne D. TNAP as a therapeutic target for cardiovascular calcification – a discussion of its pleiotropic functions in the body. Cardiovasc Res 2020 Oct 18:cvaa299. Partner 1, 2 and 3

Bessueille L, Briolay A, Como J, Mebarek S, Mansouri C, Gleizes M, El Jamal A, Buchet R, Dumontet C, Matera EL, Mornet E, Millan JL, Fonta C, Magne D. Tissue-nonspecific alkaline phosphatase is an anti-inflammatory nucleotidase. Bone. 2020 Apr;133:115262. Partner 1

Mechtouff L, Sigovan M, Douek P, Costes N, Le Bars D, Mansuy A, Haesebaert J, Bani-Sadr A, Tordo J, Feugier P, Millon A, Luong S, Si-Mohamed S, Collet-Benzaquen D, Canet-Soulas E, Bochaton T, Crola Da Silva C, Paccalet A, Magne D, Berthezene Y, Nighoghossian N. Simultaneous assessment of microcalcifications and morphological criteria of vulnerability in carotid artery plaque using hybrid 18F-NaF PET/MRI. J Nucl Cardiol 2020 Nov 3. doi: 10.1007/s12350-020-02400-0. Partner 1

Veschi EA, Bolean M, Strzelecka-Kiliszek A, Bandorowicz-Pikula J, Pikula S, Granjon T, Mebarek S, Magne D, Ramos AP, Rosato N, Millán JL, Buchet R, Bottini M, Ciancaglini P. Localization of Annexin A6 in Matrix Vesicles During Physiological Mineralization. Int J Mol Sci 2020 Feb 18;21(4):1367. doi: 10.3390/ijms21041367. Partner 1 and 3

Plaut JS, Strzelecka-Kiliszek A, Bozycki L, Pikula S, Buchet R, Mebarek S, Chadli M, Bolean M, Simao AMS, Ciancaglini P, Magrini A, Rosato N, Magne D, Girard-Egrot A, Farquharson C, Esener SC, Millan JL, Bottini M. Quantitative atomic force microscopy provides new insight into matrix vesicle mineralization. Arch Biochem Biophys. 2019 May 30;667:14-21. Partner 1 and 3

Strzelecka-Kiliszek A, Romiszewska M, Bozycki L, Mebarek S, Bandorowicz-Pikula J, Buchet R, Pikula S. Src and ROCK Kinases Differentially Regulate Mineralization of Human Osteosarcoma Saos-2 Cells. Int J Mol Sci. 2019 Jun 12;20(12):2872. doi: 10.3390/ijms20122872. Partner 1 and 3

Roszkowska M, Strzelecka-Kiliszek A, Bessueille L, Buchet R, Magne D, Pikula S. Collagen promotes matrix vesicle-mediated mineralization by vascular smooth muscle cells. J Inorg Biochem. 2018 Sep;186:1-9. Partner 1 and 3

Goettsch C, Kjolby M, Aikawa E. Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):19-25. Partner 2

Fakhry M, Roszkowska M, Briolay A, Bougault C, Guignandon A, Diaz-Hernandez JI, Diaz-Hernandez M, Pikula S, Buchet R, Hamade E, Badran B, Bessueille L, Magne D. TNAP stimulates vascular smooth muscle cell trans-differentiation into chondrocytes through calcium deposition and BMP-2 activation: Possible implication in atherosclerotic plaque stability. Biochim Biophys Acta Mol Basis Dis. 2017 Mar;1863(3):643-653. Partner 1 and 3

Goettsch C, Iwata H, Hutcheson JD, O'Donnell CJ, Chapurlat R, Cook NR, Aikawa M, Szulc P, Aikawa E. Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men. Arterioscler Thromb Vasc Biol. 2017 May;37(5):1005-1011. Partner 2

Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E. A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification. Atherosclerosis. 2016 Aug;251:109-118. Partner 2

Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh W, Yabusaki K, Faits T, Bouten C, Franck G, Quillard T, Libby P, Aikawa M, Weinbaum S, Aikawa E. Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques. Nat Mater. 2016 Mar;15(3):335-43. Partner 2

Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E. Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. J Clin Invest. 2016 Apr 1;126(4):1323-36. Partner 2

Roszkowska M, Strzelecka-Kiliszek A, Magne D, Pikula S, Bessueille L. Membranes and pathophysiological mineralization. Postepy Biochem. 2016;62(4):511-517. Review. Partner 1 and 3

Bessueille L, Magne D. Inflammation: a culprit for vascular calcification in atherosclerosis and diabetes. Cell Mol Life Sci. 2015 Jul;72(13):2475-89. Partner 1

Ren Z, Do le D, Bechkoff G, Mebarek S, Keloglu N, Ahamada S, Meena S, Magne D, Pikula S, Wu Y, Buchet R. Direct determination of phosphatase activity from physiological substrates in cells. PLoS One. 2015 Mar 18;10(3):e0120087. Partner 1 and 3

Buchet R, Pikula S, Magne D, Mebarek S. Isolation and characteristics of matrix vesicles. Methods Mol Biol. 2013;1053:115-24. Partner 1 and 3

Buchet R, Millán JL, Magne D. Multisystemic functions of alkaline phosphatases. Methods Mol Biol. 2013;1053:27-51. Partner 1

New SE, Goettsch C, Aikawa M, Marchini JF, Shibasaki M, Yabusaki K, Libby P, Shanahan CM, Croce K, Aikawa E. Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques. Circ Res. 2013 Jun 21;113(1):72-7. Partner 2

Lencel P, Delplace S, Pilet P, Leterme D, Miellot F, Sourice S, Caudrillier A, Hardouin P, Guicheux J, Magne D. Cell-specific effects of TNF-α and IL-1β on alkaline phosphatase: implication for syndesmophyte formation and vascular calcification. Lab Invest. 2011 Oct;91(10):1434-42. Partner 1

Lencel P, Hardouin P, Magne D. Do cytokines induce vascular calcification by the mere stimulation of TNAP activity? Med Hypotheses. 2010 Dec;75(6):517-21. Partner 1